A Cluster-Randomized Controlled Trial Evaluating the Effects of Mass Azithromycin Treatment on Growth and Nutrition in Niger

作者：Amza Abdou; Kadri Boubacar; Nassirou Baido; Stoller Nicole E; Yu Sun N; Zhou Zhaoxia; West Sheila K; Mabey David C W; Bailey Robin L; Keenan Jeremy D; Porco Travis C; Lietman Thomas M; Gaynor Bruce D^*

来源：The American Journal of Tropical Medicine and Hygiene, 2013, 88(1): 138-143.

DOI：10.4269/ajtmh.2012.12-0284

Antimicrobials are used primarily to treat infectious disease, but they have other effects. Here, we assess anthropometry measurements in children 6-60 months in 24 communities randomized to one or two mass azithromycin distributions over a 1-year period in Niger. We compared the prevalence of wasting, low mid-upper arm circumference, stunting, and underweight in communities in the two treatment arms. We were unable to prove that there was a difference in the prevalence of wasting in the 12 communities that received one mass azithromycin distribution versus the 12 communities that received two mass azithromycin distributions (odds ratio = 0.75, 95% confidence interval = 0.46-1.23). Likewise, we were unable to detect a difference in the two treatment arms for low mid-upper arm circumference, stunting, and underweight. There may not be an association between antibiotic use and improved growth in humans, or this trial was not powerful enough to detect an association if it exists.

• 出版日期2013-1