Autism spectrum disorder in individuals with anorexia nervosa and in their first- and second-degree relatives: Danish nationwide register-based cohort-study

作者：Koch Susanne V^*; Larsen Janne T; Mouridsen Svend E; Bentz Mette; Petersen Liselotte; Bulik Cynthia; Mortensen Preben B; Plessen Kerstin J

来源：The British Journal of Psychiatry, 2015, 206(5): 401-407.

DOI：10.1192/bjp.bp.114.153221

Background
Clinical and population-based studies report increased prevalence of autism spectrum disorders (ASD) in individuals with anorexia nervosa and in their relatives. No nationwide study has yet been published on co-occurrence of these disorders.
Aims
To investigate comorbidity of ASD in individuals with anorexia nervosa, and aggregation of ASD and anorexia nervosa in their relatives.
Method
In Danish registers we identified all individuals born in 1981-2008, their parents, and full and half siblings, and linked them to data on hospital admissions for psychiatric disorders.
Results
Risk of comorbidity of ASD in probands with anorexia nervosa and aggregation of ASD in families of anorexia nervosa probands were increased. However, the risk of comorbid and familial ASD did not differ significantly from comorbid and familial major depression or any psychiatric disorder in anorexia nervosa probands.
Conclusions
We confirm aggregation of ASD in probands with anorexia nervosa and in their relatives; however, the relationship between anorexia nervosa and ASD appears to be nonspecific.

• 出版日期2015-5
• 单位上海市精神卫生中心