No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset

作者：Heron Elizabeth A^*; Cormican Paul; Donohoe Gary; O' Neill Francis A; Kendler Kenneth S; Riley Brien P; Gill Michael; Corvin Aiden P; Morris Derek W

来源：Schizophrenia Research, 2014, 154(1-3): 79-82.

DOI：10.1016/j.schres.2014.01.038

• Runs of homozygosity
• GWAS
• Schizophrenia
• Rare variant
• Mutation

Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present in a homozygous and potentially recessive state. To detect rare risk variants for schizophrenia, we performed an ROH analysis in a homogeneous Irish genome wide association study (GWAS) dataset consisting of 1606 cases and 1794 controls. There was no genome-wide excess of ROH in cases compared to controls (p = 0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction.

• 出版日期2014-4