科研之友
微信
新浪微博
Facebook
分享链接
摘要
The catalyst-free, regioselective synthesis of 4'-O-substituted pyridoxine derivatives under solventless conditions is described. The methodology relies on the highly regioselective formation of the ortho-pyridinone methide from pyridoxine and subsequent oxa-Michael addition of alcohol nucleophiles. This methodology provides good to excellent yields for primary and secondary alcohols and moderate yields for tertiary alcohols.
- 出版日期2017-6-7
