Hereditary isolated metatarsophalangeal arthritis

作者：Nissi R^*; Perhomaa M; Silvennoinen L; Halonen V; Rasila R; Winblad I; Ignatius J

来源：Scandinavian Journal of Rheumatology, 2011, 40(1): 22-25.

DOI：10.3109/03009742.2010.495081

Objective: To describe a family with 13 members in four generations affected by early-onset isolated painful arthritis limited to the first metatarsophalangeal (MTP) joint but without evidence of generalized joint disease at follow-up.
Methods: A complete family pedigree was constructed and radiographs from the affected family members and their offspring were taken. Laboratory tests including serum measurements of C-reactive protein (CRP), urate, and rheumatoid factor (RF) were performed to exclude gout and rheumatoid arthritis from the diagnosis.
Results: The age at onset of first MTP joint symptoms varied from 12 to 51 years. Both females and males were affected in the four successive generations, including male-to-male transmission as well as maternal inheritance. The affected patients were often treated surgically with good pain-relieving results.
Conclusion: To our knowledge, this is the first report of early-onset isolated foot metatarsal arthritis with apparent autosomal dominant inheritance.

• 出版日期2011-2