Altered basal ganglia network integration in schizophrenia

作者：Duan, Mingjun; Chen, Xi; He, Hui; Jiang, Yuchao; Jiang, Sisi; Xie, Qiankun; Lai, Yongxiu; Luo, Cheng^*; Yao, Dezhong

来源：Frontiers in Human Neuroscience, 2015, 9: 561.

DOI：10.3389/fnhum.2015.00561

• basal ganglia network
• resting-state fMRI
• independent component analysis
• functional connectivity
• schizophrenia

The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilateral caudate nucleus in schizophrenia patients. Further, the caudate nucleus in patients showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia patients. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number ChiCTR-RCS-14004878.

• 出版日期2015-10-12
• 单位电子科技大学