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摘要
Hyperthermia has been one of the most promising cancer therapies. However, it requires an accurate thermal dosage in the treatment planning for a safe and effective exposure. This paper describes multi-scale theoretical approaches to evaluate the systemic temperature response of a human body subject to 10 W localized heating. The systemic bioheat transfer is modeled as a 49 compartment system with temperature-based feedback control. At the tissue level, bioheat transfer described by Pennes' equation is solved by the finite-element method. Two multiscale simulations are considered. The first one is performed based on the assumption of homogenous temperature-distribution yet inhomogeneous heat deposition. It can pass non-temperature-dependent variables from local parts to global sites. Three properties of the source are thus studied. The second simulation is a combination of the compartment model and Pennes' bioheat equation. It can also calculate strongly coupled variables dependent not only on space or time but also on temperature distribution. To compare the heat-delivery efficiency, benchmarks are developed to assess various hyperthermia modalities within a well-defined region of interest. The result from the first simulation shows a complex temperature-increment index (CTII) with a halved homogeneous temperature-increment coefficient (HTIC) when heated near vessel. The second simulation of extremity heating indicates a similar phenomenon of heat transport between tissues via blood perfusion rather than conduction. Both simulations show that up to 0.2-0.5 and 0.3A degrees C increase in blood and brain temperature, respectively, were induced, which cannot be ignored in large dosage or long duration of localized heating during thermal ablation on a tumor.
- 出版日期2011-8
- 单位中国科学院理化技术研究所; 东北大学; 清华大学
