科研之友
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摘要
A novel approach to 3-polyfluoroalkyl pyrroles is reported based on step by step reactions: 1,2-addition of Me(3)SiCN to beta-alkoxyvinyl polyfluoroalkyl ketones, reduction with LiAlH(4) and subsequent hydrolysis with intramolecular cyclization. The hydrolytic instability of various polyfluoroalkyl groups at position 3 of the pyrrole ring was evident and a pathway for the hydrolysis was proposed.
- 出版日期2008-2-11
