Automatic Formation of Hypotheses on the Relationships between Structure of Naphthalene Analogs and Bioluminescence Response of Bioreporter Pseudomonas fluorescens HK44

作者：Troegl J^*; Halova J; Kuncova G; Parik P

来源：Folia Microbiologica, 2010, 55(5): 411-417.

DOI：10.1007/s12223-010-0069-7

Seven hypotheses on relationships between the structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens were formulated using GUHA (General Unary Hypotheses Automaton) on a training set of 37 compounds. Prediction of bioluminescence response of 12 new naphthalene analogs was successful in 69 % cases and resulted in rejection of single hypothesis. The results demonstrate applicability of GUHA in structure-activity research, especially for qualitative data.

• 出版日期2010-9