Differential Response to Methylphenidate in Inattentive and Combined Subtype ADHD

作者：Beery Susan H^*; Quay Herbert C; Pelham William E Jr

来源：Journal of Attention Disorders, 2017, 21(1): 62-70.

DOI：10.1177/1087054712469256

• ADHD subtypes
• methylphenidate
• medication treatment

Objective: To examine response to methylphenidate (MPH) assessed by direct observation of ecologically valid behaviors in boys with ADHD with high hyperactivity-impulsivity (HI) and those with predominantly inattentive symptoms (ADHD/I). Method: Sixty-three boys ages 7 to 13 participated in an ADHD Summer Treatment Program and received a double-blind placebo-controlled assessment of .3 mg/kg of MPH on problem behaviors and individualized behavior goals. Medication effect sizes were calculated for each child for each behavior. Results: Children with ADHD/HI (n = 21) displayed larger MPH effect sizes for interrupting, verbal abuse, and compliance, and marginally greater response for teasing and counselor-directed goals. Children with ADHD/I (n = 21) displayed small medication effect sizes (ds < .20) for many behaviors often identified as primary deficits in this group (e.g., attention to activities, peer interaction, class work completion, and accuracy). Conclusion: Systematic medication assessment for ADHD/I that quantifies response in ecologically valid areas of functional impairment is essential.

• 出版日期2017-1