Aspirin-intolerant asthma in the Korean population: Prevalence and characteristics based on a questionnaire survey

作者：Moon Ji Yong; Kim Sang Heon; Kim Tae Bum; Kim Sae Hoon; Chang Yoon Seok; Lee Jae Hyun; Cho You Sook; Park Jung Won; Jang An Soo; Park Choon Sik; Nahm Dong Ho; Cho Young Joo; Cho Sang Heon; Choi Byoung Whui; Moon Hee Bom; Yoon Ho Joo^*

来源：Respiratory Medicine, 2013, 107(2): 202-208.

DOI：10.1016/j.rmed.2012.10.020

• Aspirin-intolerant asthma
• Prevalence
• Characteristics

Background: Aspirin-intolerant asthma is a unique clinical syndrome characterized by acute bronchoconstriction following the administration of aspirin and/or non-steroidal anti-inflammatory drugs. %26lt;br%26gt;Objective: We assessed the prevalence and investigated the demographic and clinical characteristics of adult patients with aspirin-intolerant asthma in Korea. %26lt;br%26gt;Methods: Using an adult asthma cohort (COREA) from 11 university hospitals in Korea, we analyzed the prevalence of aspirin-intolerant asthma, defined as a positive response to the question: %26quot;Have you ever experienced dyspnea and cough after taking an aspirin or any NSAID (cold medicine)?%26quot; Demographic and clinical characteristics were compared between patients with aspirin-intolerant asthma and aspirin-tolerant asthma. %26lt;br%26gt;Results: Aspirin-intolerant asthma was reported in 68 (5.8%) of 1173 adult asthmatics (age 15 84). Patients with aspirin-intolerant asthma had a lower mean age (43.9 +/- 13.4 vs. 49.0 +/- 15.6, P = 0.003) and a higher prevalence of rhinosinusitis (77.9% vs. 61.7%, P = 0.012) and atopic dermatitis (16.2% vs. 5.7%, P = 0.001) than aspirin-tolerant asthma patients. There were no significant differences in lung function, asthma severity or the use of asthma controllers. However, aspirin-intolerant asthma was associated with greater use of healthcare services over a lifetime and over the past 12 months. Aspirin-intolerant asthma was significantly associated with emergency room visits over the past 12 months (P = 0.029, OR 2.19, 95% Cl 1.08-4.42). %26lt;br%26gt;Conclusion: Based on histories, the prevalence of aspirin-intolerant asthma is 5.8% among adult asthma patients in Korea. Aspirin-intolerant asthma is associated with lower age, higher prevalence of rhinosinusitis and atopic dermatitis, and more frequent exacerbations.

• 出版日期2013-2