Ultrasmall Polyethyleneimine-Gold Nanoparticles with High Stability

作者：Kim Eun Jung; Yeum Jeong Hyun^*; Ghim Han Do; Lee Se Guen; Lee Ga Hyun; Lee Hyun Ju; Han Sang Ik; Choi Jin Hyun

来源：Polymer-Korea, 2011, 35(2): 161-165.

DOI：10.7317/pk.2011.35.2.161

• gold
• nanoparticles
• polyethyleneimine
• reductant
• stabilizer

This study is related to the preparation of biocompatible gold nanoparticles (AuNPs) which are stable in aqueous solutions for a long time. Ultrasmall polyethyleneimine (PEI)-capped AuNPs (PEI-AuNPs) with limited agglomeration were prepared in aqueous solutions at room temperature, which were based on the roles of PEI as a reductant and a stabilizer. PEI-AuNPs with an average size of 8-12 nm formed highly stable nanocolloids with an average hydrodynamic cluster size of around 50 nm in aqueous media. At a low concentration of metal precursor hydrogen tetrachloroaurate OM, the particle size was reduced noticeably. The typical peaks of gold were observed in the X-ray diffraction pattern of AuNPs. The cell viability of 98% was obtained in the case of PEI-AuNPs, while PEI was cytotoxic. The PEI-AuNP is considered to be a potential candidate as a contrast agent for computed tomography.

• 出版日期2011-3