A novel organogermanium protected atopic dermatitis induced by oxazolone

作者：Lim Doo Hyeon; Li Minghua; Seo Jung A; Lim Kyung Min; Ham Seung Wook^*

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(14): 4032-4034.

DOI：10.1016/j.bmcl.2010.05.097

• Organogermanium
• Atopic dermatitis (AD)
• Murine model
• Anti-AD activities

Atopic dermatitis ( AD) is a chronic inflammatory disease of the skin that is often associated with other atopic diseases, such as asthma and allergic rhinitis. Although topical steroids have widely been prescribed for patients with AD, skin abnormalities are frequently observed after prolonged steroid treatment. In this study, a novel water-soluble organogermanium compound (Ge-Vit) was prepared because organogermanium is a known INF-gamma inducer. The Ge-Vit treatment decreased the basal TEWL and IgE production and attenuated the disruption of the skin barrier function in a murine model of chronic contact dermatitis. The histological examination further supported the anti-AD activities. These results suggested that Ge-Vit can be a useful drug candidate for treating atopic dermatitis.

• 出版日期2010-7-15