Neuroendocrine control of feeding behavior and psychomotor activity by neuropeptideY in fish

作者：Matsuda Kouhei^*; Sakashita Atsushi; Yokobori Eri; Azuma Morio

来源：Neuropeptides, 2012, 46(6): 275-283.

DOI：10.1016/j.npep.2012.09.006

• Neuropeptide Y
• Goldfish
• Zebrafish
• Food intake
• Orexigenic action
• Emotional behavior
• Anxiolytic action

Neuropeptide Y (NPY) is a neuropeptide distributed widely among vertebrates. In mammals, NPY and its related peptides such as pancreatic polypeptide and peptide YY (PYY) are distributed throughout the brain and gastrointestinal tissues, and are centrally involved in many physiological functions such as the regulation of food intake, locomotion and psychomotor activities through their receptors. With regard to non-mammalian vertebrates, there has also been intensive study aimed at the identification and functional characterization of NPY, PYY and their receptors, and recent investigations of the role of NPY have revealed that it exerts several behavioral effects in goldfish and zebrafish. Both of these species are excellent teleost fish models, in which it has been demonstrated that NPY increases food consumption as an orexigenic factor and reduces locomotor activity, as is the case in mammals. This paper reviews current knowledge of NPY derived from studies of teleost fish, as representative non-mammals, focusing particularly on the role of the NPY system, and examines its significance from a comparative viewpoint.

• 出版日期2012-12