An immunomodulator from Terminalia arjuna and biological evaluation of its derivatives

作者：Saxena Mohit; Yadav Sachidanand; Bawankule Dhyaneshwar U; Srivastava Santosh K^*; Pal Anirban; Mishra Rupal; Gupta Madan M; Darokar Mahendra P; Priyanka; Khanuja Suman P S

来源：Natural Product Communications, 2008, 3(6): 891-894.

DOI：10.1177/1934578x0800300613

• Terminalia arjuna
• arjunic acid derivatives
• immunomodulatory
• immunostimulatory
• immunosuppressive

Detailed chemical investigation of Terminalia arjuna bark resulted in the isolation and identification of an immunomodulatory constituent, arjunic acid (1), which was converted into seven semi-synthetic derivatives (2-8). All the test compounds in 0.1, 1 and 10 mu g/mL concentrations exhibited immunomodulatory effects in a dose dependant manner. 2-O-Lauroyl arjunic acid (3) and 2-O-palmitoyl arjunic acid (4) exhibited immunostimulatory response at all the tested concentrations, while arjunic acid (1), 2,3-di-O-acetyl arjunic acid (2), 2,3-di-O-benzoyl arjunic acid (6), and 2-O-p-anisoyl arjunic acid (7) exhibited immunostimulatory responses at lower doses, whereas at higher concentrations they exhibited immunosuppressive activity. Only 2,3-di-O-palmitoyl arjunic acid (5) showed immunosuppressive activity at all the concentrations; this is being reported for the first time.

• 出版日期2008
• 单位河北医科大学