Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus

作者：Pantham Ganesh; Ganesan Santhi; Einstadter Douglas; Jin Ge; Weinberg Aaron; Fass Ronnie^*

来源：DISEASES OF THE ESOPHAGUS, 2017, 30(1): n/a-n/a.

DOI：10.1111/dote.12475

• esophageal papilloma
• esophageal squamous cell carcinoma
• human papilloma virus

Background and Aims: There has been a recent increase in the incidence of oropharyngeal cancer (OPC) associated with high-risk human papilloma virus (HPV) infection. We investigated the incidence of esophageal papilloma and the presence of high-risk HPV infection. Methods: This is a cross-sectional study conducted at a County teaching hospital. Patients with esophageal papilloma between January 2000 and December 2013 were identified. Patients with sufficient specimens were tested for the HPV virus. Results: Sixty patients with esophageal papilloma lesions were identified from 2000 to 2013. (31 males, age 51 +/- 13 years). The incidence was 0.13% in 2000 and increased to 0.57% in 2013 (P < 0.0001). Twenty-nine patients (48.3%) had a papilloma that was more than 5 mm in size, and 20% had multiple lesions. The papilloma was located in the distal esophagus in 35 (58.3%) patients, mid esophagus in 17 (28.3%) patients, and proximal in 8 (13.3%) patients. Three (5%) patients had associated OPC, and 9 (47.4%) of the 19 patients tested were positive for high-risk HPV serotype 16. Conclusions: The incidence of esophageal papilloma has increased by fourfolds over the past 14 years. About half of the tested patients demonstrated high risk HPV. This may suggest a potential growing risk for esophageal squamous cell cancer in the future.

• 出版日期2017-1