DTI segmentation via the combined analysis of connectivity maps and tensor distances

作者：Barbieri Sebastiano^*; Bauer Miriam H A; Klein Jan; Moltz Jan; Nimsky Christopher; Hahn Horst K

来源：NeuroImage, 2012, 60(2): 1025-1035.

DOI：10.1016/j.neuroimage.2012.01.076

• Segmentation
• Diffusion tensor imaging
• Non parametric
• Riemannian manifold
• Phantom
• Connectivity
• Variational noise

We describe a novel approach to extract the neural tracts of interest from a diffusion tensor image (DTI). Compared to standard streamline tractography, existing probabilistic methods are able to capture fiber paths that deviate from the main tensor diffusion directions. At the same time, tensor clustering methods are able to more precisely delimit the border of the bundle. To the best of our knowledge, we propose the first algorithm which combines the advantages supplied by probabilistic and tensor clustering approaches. The algorithm includes a post-processing step to limit partial-volume related segmentation errors. We extensively test the accuracy of our algorithm on different configurations of a DTI software phantom for which we systematically vary the image noise, the number of gradients, the geometry of the fiber paths and the angle between adjacent and crossing fiber bundles. The reproducibility of the algorithm is supported by the segmentation of the corticospinal tract of nine patients. Additional segmentations of the corticospinal tract, the arcuate fasciculus, and the optic radiations are in accordance with anatomical knowledge. The required user interaction is comparable to that of streamline tractography, which allows for an uncomplicated integration of the algorithm into the clinical routine.

• 出版日期2012-4-2
• 单位河北医科大学