Association between COMT Val158Met polymorphism and preeclampsia in the Chinese Han population

作者：Zhao, Xiaohua; Liu, Jingjing; Zhao, Cuisheng; Ye, Ping; Ji, Jing; Wang, Jingli; Song, Weiqing; Xu, Jine^*; Liu, Shiguo^*

来源：Hypertension in Pregnancy, 2016, 35(4): 565-572.

DOI：10.1080/10641955.2016.1211677

• COMT
• polymorphism
• preeclampsia
• val158Met(rs4680)

Objective: Previous studies have been indicated that catechol-O-methyltransferase gene (COMT) might play a significant role in the development of preeclampsia (PE). Our study aims to investigate the association between polymorphism in COMT with the susceptibility to PE in Chinese Han women. Method: A total of 1028 PE patients and 1399 normal pregnant women were enrolled. We detected the genotyping of COMT Val158Met loci by the TaqMan allelic discrimination real-time PCR . Results: No significant difference in the genotypic and allelic distribution was found between the two groups (genotype: X-2 = 0.583, p = 0.747; allele:X-2 = 0.526, p = 0.468). Conclusion: The COMT Val158Met polymorphism might not be associated with PE in Chinese women.

• 出版日期2016-11
• 单位青岛市市立医院; 甘肃省妇幼保健院; 临沂市人民医院; 青岛大学