Antiproliferative Activity of Silver Nanoplates on Human Promyelocytic Leukemia Cell Lines

作者:Sakaguchi Tatsuya; Mine Kenta; Kudoh Fuki; Kamada Rui; Sakaguchi Kazuyasu*
来源:Chemistry Letters, 2015, 44(3): 327-329.
DOI:10.1246/cl.141085

摘要

The physical and chemical properties of silver nanomaterials are highly dependent on their shape and size. Recently, Ag nanoparticles have been reported to be useful for medicinal and pharmaceutical applications including anticancer activity. In this study, we showed that Ag nanoplates possess significantly higher antiproliferative activity on human promyelocytic leukemia cells, HL-60, than spherical nanoparticles. The triangular Ag nanoplates induced apoptosis in the cells and were located in the same subcellular compartment as the spherical Ag nanoparticles.

  • 出版日期2015-3-5

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