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摘要
A straightforward entry to chiral carbocyclic nucleoside analogues has been realized via the enantioselective [3+2] cycloaddition of alpha-nucleobase substituted acrylates to vinyl cyclopropanes for the first time. With Pd-2(dba)(3)-L5 as the catalyst, carbocyclic purine, uracil, and thymine nucleoside analogues with quaternary stereo-centers were obtained in excellent yields (up to 99% yield) and good enantioselectivities (up to 92% ee).
- 出版日期2015
- 单位河南师范大学
