Genetic determination in onset age of wrist fracture

作者：Xiong, Donghai; Wang, Wei; Chen, Yuan; Jiang, Hui; Deng, Hong Wen^*

来源：Journal of Human Genetics, 2007, 52(6): 481-484.

DOI：10.1007/s10038-007-0141-6

• onset age
• wrist fracture
• heritability

The onset age of fracture may be useful to explore the clinical and genetic heterogeneity of fracture study. In the present study, we investigated the heritability of the onset age of wrist fracture (OAWF) in 30 female full-sib pairs. The phenotypic correlation coefficient of OAWF was 0.309 (P = 0.09) for this cohort of female sib pairs, and the narrow-sense heritability (h(2)) was estimated to be 0.618 (P = 0.09). In addition, the h(2) derived from the variance component model implemented in SOLAR was 0.722 (P < 0.05). This study, for the very first time, suggested that OAWF is under genetic control and thus potentially helps clarify genetic heterogeneity of wrist fracture.

• 出版日期2007-6
• 单位湖南师范大学; 西安交通大学