Adjuvant radiotherapy after extrapleural pneumonectomy for mesothelioma. Prospective analysis of a multi-institutional series

作者：Tonoli Sandro; Vitali Paola; Scotti Vieri; Bertoni Filippo; Spiazzi Luigi; Ghedi Barbara; Buonamici Fabrizio Banci; Marrazzo Livia; Guidi Gabriele; Meattini Icro; Bastiani Paolo; Amichetti Maurizio; Schwarz Marco; Magrini Stefano Maria^*

来源：Radiotherapy and Oncology, 2011, 101(2): 311-315.

DOI：10.1016/j.radonc.2011.09.025

• Malignant pleural mesothelioma
• Radiotherapy
• Extrapleural pneumonectomy
• IMRT

Background and purpose: To evaluate survival, locoregional control and toxicity in a series of 56 mesothelioma patients treated from May 2005 to May 2010 with post-operative radiotherapy after extrapleural pneumonectomy (EPP) in three Italian Institutions (Brescia, Florence, and Modena). Material and methods: Fifty-six patients treated with adjuvant radiotherapy (RT) after EPP were analyzed. Four patients were treated with 3DCRT, 50 with IMRT and two with helical tomotherapy. Forty-five to 50 Gy in 25 fractions were given to the affected hemithorax and to ipsilateral mediastinum, with a simultaneous integrated boost to the sites of microscopically involved margins up to 60 Gy in 20/56 cases. Results: Three year locoregional control (LRC), distant metastasis free (DMF), disease free (DF), disease specific (DSS) and overall survival (OS) rates are 90%, 66%, 57%, 62%, and 60%, respectively. Conclusion: Postoperative RT with modern techniques is an effective method to obtain excellent local control and cure rates in mesothelioma patients submitted to EPP.

• 出版日期2011-11