Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent

作者：Sashidhara Koneni V^*; Singh Suriya P; Srivastava Anuj; Puri Anju; Chhonker Yashpal S; Bhatta Rabi S; Shah Priyanka; Siddiqi Mohammad Imran

来源：European Journal of Medicinal Chemistry, 2011, 46(10): 5206-5211.

DOI：10.1016/j.ejmech.2011.08.012

• Polyalthia longifolia var. pendula
• Clerodane diterpene
• Lipid lowering activity
• 3-Hydroxy-3-methylglutaryl-CoA reductase
• Hamsters

Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula, led to the discovery of the clerodane diterpene, 16 alpha-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (1), as a new structural class of HMG-CoA reductase inhibitor. Importantly, the in vivo effects of 1 corroborated well with its molecular docking analysis and also with its hamster plasma pharmacokinetics.

• 出版日期2011-10