Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice

作者：van Es T; van Puijvelde G H M; Ramos O H; Segers F M E; Joosten L A; van den Berg W B; Michon I M; de Vos P; van Berkel Th J C; Kuiper J^*

来源：Biochemical and Biophysical Research Communications, 2009, 388(2): 261-265.

DOI：10.1016/j.bbrc.2009.07.152

• Atherosclerosis
• LDL receptor deficient mice
• Interleukin-17
• Bone marrow transplantation

Atherosclerosis is an inflammatory disease characterized by the influx of macrophages and T cells and IL-17 may connect innate and adaptive immune responses involved in atherogenesis. We investigated the role of IL-17 receptor signaling in atherosclerosis and transplanted LDLr deficient recipient mice with IL-17R deficient bone marrow. Induction of atherosclerosis by Western-type diet induced a 46% reduction in lesion size in the aortic root and the plaque composition revealed no significant changes in collagen content and neutrophil counts, but a reduction in mast cell number and an increase in macrophage number. In addition, we observed a decrease in anti-oxLDL antibodies of the IgG class upon IL-17R BMT, while introduction of IL-17R deficient bone marrow resulted in a reduced IL-6 production and an increased IL-10 production.
In conclusion, signaling via the IL-17 receptor in bone marrow derived cells enhances the process of atherosclerosis.

• 出版日期2009-10-16