Gandoderma lucidum Extract Promotes Immune Responses in Normal BALB/c Mice In Vivo

作者：Chang Yung Hsien; Yang Jai Sing; Yang Jiun Long; Wu Chang Lin; Chang Shu Jen; Lu Kung Wen; Kuo Chao Lin; Hsia Te Chun; Chung Jing Gung^*

来源：In Vivo, 2009, 23(5): 755-759.

• Ganoderma lucidum extract
• BALB/c mice
• interleukin-6
• interferon-gamma
• phagocytosis

Enhanced fruit and vegetable consumption is closely related to reduced cancer incidence as shown in epidemiological studies. Ganoderma lucidum, one of the most well-known traditional Chinese medicines, has been demonstrated to have pharmacological activities and antitumor effects, in Asian populations. However, the promotion of immune responses in normal BALB/c mice is unclear. In the present study, we investigated the immune responses of BALB/c mice after treatment with G. lucidum extract in vivo. The results demonstrated that G. lucidum extract was able to promote the proliferation of splenocytes under Concanavalin A or lipopolysaccharide stimulation. Compared with the control group, phagocytosis of macrophage was significantly enhanced by intraperitoneal administration of G. lucidum extract at both 3 and 6 mg/kg. Compared with the control group, natural killer cell activity was significantly enhanced by intraperitoneal administration of G. lucidum extract (6 mg/kg). Results of cytometric bead array and flow cytometry indicated that the expressions of interleukin-6 and interferon-gamma also increased (p<0.001) by treatment with G. lucidum extract (3 and 6 mg/kg). In conclusion, the findings of this study implied that G. lucidum extract was able to effectively promote immune responses in BALB/c mice.

• 出版日期2009-10
• 单位中国医科大学