Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population

作者：Zhu X L; Meng H X^*; Zhang L; Xu L; Chen Z B; Shi D; Feng X H; Zhang X

来源：Journal of Periodontal Research, 2012, 47(3): 286-292.

DOI：10.1111/j.1600-0765.2011.01426.x

• aggressive periodontitis
• genetics
• monocyte chemoattractant protein 1 (MCP-1)
• monocytes

Background and Objective: It has been suggested that aggressive periodontitis has a genetic basis. Monocyte chemoattractant protein 1 (MCP-1) plays a critical role in the recruitment of monocytes and the development of periodontitis. The) 2518MCP-1(A/ G) polymorphism has been implicated as a risk or susceptibility factor for a variety of autoimmune conditions and inflammatory diseases. The intent of this investigation was to study whether the) 2518MCP-1(A/ G) polymorphism is associated with generalized aggressive periodontitis in the Chinese population. Material and Methods: One hundred and twenty-four patients with generalized aggressive periodontitis and 94 healthy subjects were included in this case-control study. Genomic DNA was isolated from a peripheral blood sample obtained from each subject. Gene polymorphisms of) 2518MCP-1(A/ G) were analyzed by a standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A logistic regression analysis was performed to test the association between the) 2518MCP-1(A/ G) genotype (alleles) and generalized aggressive periodontitis with adjustment of the major covariates (gender, age and smoking status). Results: There was no significant association of the) 2518MCP-1(A/ G) polymorphism with generalized aggressive periodontitis in the unstratified subjects. However, when patients were stratified by gender, the frequency of the G + genotype was significantly lower in female patients with generalized aggressive periodontitis compared with female controls (p = 0.036, adjusted odds ratio = 0.3, 95% CI: 0.1-0.9). In female patients with generalized aggressive periodontitis, the probing pocket depth was larger in subjects with the AA genotype than in subjects with the G + genotype (5.07 mm vs. 4.30 mm; Z =) 2.470, p = 0.014). Conclusion: The polymorphisms of) 2518MCP-1 may play an important role in determining generalized aggressive periodontitis susceptibility in this cohort of Chinese women.

• 出版日期2012-6
• 单位北京大学