科研之友
微信
新浪微博
Facebook
分享链接
摘要
Total syntheses of (-)-variabilin and (-)-glycinol have been accomplished, using the catalytic, asymmetric "Interrupted" Feist-Benary reaction (IFB) as the key transformation to introduce both stereogenic centers. A monoquinidine pyrimidinyl ether catalyst affords the IFB products In over 90% ee in both cases. Other key steps include an intramolecular Buohwald-Hartwig coupling and a nickel-catalyzed aryl tosylate reduction.
- 出版日期2011-7-15
