Association of post-treatment positron emission tomography with locoregional control and survival after radiation therapy for squamous cell carcinoma of the vulva

作者：Rao Yuan James; Hassanzadeh Comron; Chundury Anupama; Hui Caressa; Siegel Barry A; Dehdashti Farrokh; DeWees Todd; Mullen Daniel; Powell Matthew; Mutch David; Schwarz Julie; Grig**y Perry

来源：Radiotherapy and Oncology, 2017, 122(3): 445-451.

DOI：10.1016/j.radonc.2016.12.019

• Vulvar cancer
• Radiation
• FDG-PET
• Squamous cell carcinoma

Background/purpose: The aim of this study was to investigate the use of post-treatment F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for vulvar cancer and compare metabolic response to clinical outcomes.
Materials/methods: This retrospective study included 21 patients with vulvar squamous cell carcinoma treated with curative-intent radiation between 2007 and 2015. All patients received intensity modulated radiation treatment (IMRT), a pre-treatment FDG/PET-CT, and a post-treatment FDG-PET/CT performed at a median time of 3 months post-IMRT.
Results: Median follow-up time was 28 months. Post-treatment FOG-PET/CT demonstrated no evidence of disease (NED) in 12 patients and residual or progressive disease (PD) in 9. FOG-PET/CT response significantly correlated with biopsy-proven locoregional failure (p = 0.02) and was the only significant factor associated with overall survival (OS) (p = 0.049). Patients with NED on FDG-PET had a 2-year locoregional control (LRC) of 89% versus 25% for those with PD (rho < 0.01). Patients with NED on FOG-PET/CT had a 2 year OS of 100% versus 42% for those with PD (p = 0.02). FDG-PET/CT evaluation had a sensitivity of 100% and a specificity of 71% for detecting pathologically proven residual disease in patients receiving neoadjuvant or definitive radiation.
Conclusion: In this single-institution study of women with vulvar cancer, post-treatment response on FOG-PET/CT was associated with LRC and OS.

• 出版日期2017-3