A Multifunctional Ribonuclease-A-Conjugated CdTe Quantum Dot Cluster Nanosystem for Synchronous Cancer Imaging and Therapy

作者:Kong, Yifei; Chen, Jun; Gao, Feng*; Li, Wenting; Xu, Xin; Pandoli, Omar; Yang, Hao; Ji, Jiajia; Cui, Daxiang
来源:Small, 2010, 6(21): 2367-2373.
DOI:10.1002/smll.201001050

摘要

CdTe quantum dot (QD) clusters are synthesized in the presence of RNase A, which acts as a biomolecular templating, agent under microwave irradiation. Red shifts of photoluminescence spectra of the denatured RNase A (dRNase A)-capping QD clusters (dRQDs) are detected during a fifty-day storage period at room temperature. Native RNase-A-associated dRQDs (R-dRQDs) are functionalized with cyclic RGD peptides for synchronous targeted cancer imaging and therapy.