A Histoplasma capsulatum-Specific IgG1 Isotype Monoclonal Antibody, H1C, to a 70-Kilodalton Cell Surface Protein Is Not Protective in Murine Histoplasmosis

作者:Lopes Livia Cristina Liporagi; Guimaraes Allan J; de Cerqueira Mariana Duarte; Gomez Beatriz L; Nosanchuk Joshua D*
来源:Clinical and Vaccine Immunology, 2010, 17(7): 1155-1158.
DOI:10.1128/CVI.00033-10

摘要

Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.

  • 出版日期2010-7