Nanocomposite biomaterial mimicking aortic heart valve leaflet mechanical behaviour

作者：Mohammadi H^*

来源：Proceedings of the Institution of Mechanical Engineers - Part H: Journal of Engineering in Medicine , 2011, 225(H7): 718-722.

DOI：10.1177/0954411911399826

• material characterization
• uniaxial tensile test
• anisotropy
• heart valve leaflet
• hyperelasticity

The main problem with polymeric heart valves (which are already biocompatible) is that they usually fail in the long term owing to tearing and calcification of the leaflets under high dynamic tensile bending stress and oxidative reactions with blood. To overcome this shortcoming, it is hypothesized that synthetic valve leaflets which mimic native valve leaflet structure fabricated from fibre-reinforced composite material will optimize leaflet stresses and decrease tears and perforations. The objective of this study is to develop a PVA-BC (polyvinyl alcohol-bacterial cellulose)-based hydrogel that mimics not only the non-linear mechanical properties displayed by porcine heart valves, but also their anisotropic behaviour. By applying a controlled strain to the PVA samples, while undergoing low-temperature thermal cycling, it was possible to create oriented mechanical properties in PVA hydrogels. The oriented stress-strain properties of porcine aortic valves were matched simultaneously by a PVA hydrogel (15 per cent PVA, 0.5 BC cycle 4, 75 per cent initial tensile strain). This novel technique allows the control of anisotropy to PVA hydrogel, and gives a broad range of control of its mechanical properties, for specific medical device applications.

• 出版日期2011