MicroSPECT imaging of triple negative breast cancer cell tumor xenografted in athymic mice with radioiodinated anti-ICAM-1 monoclonal antibody

作者：You, Linyi; Wang, Xiangyu; Guo, Zhide; Zhang, Deliang; Zhang, Pu; Li, Jindian; Su, Xinhui; Pan, Weimin; Zhang, Xianzhong^*

来源：Applied Radiation and Isotopes, 2018, 139: 20-25.

DOI：10.1016/j.apradiso.2018.04.005

• Radioiodination
• SPECT
• ICAM-1
• Triple negative breast cancer

Intercellular adhesion molecule-1(ICAM-1) is a potential molecular target and biomarker for triple negative breast cancer (TNBC) therapy and diagnosis. In this study, aICAM-1 was radioiodinated with I-125/I-131 in high radiochemical yield and the probes for TNBC tumor targeting and radioimmunotherapy were evaluated in tumor-bearing mice. High and specific accumulation of I-125-aICAM1 in TNBC MDA-MB-231 tumor was observed in SPECT imaging and the tumor grew was inhibited obviously by I-131-aICAM1. Thus, the radioiodinated aICAM1 could serve as potential agents for TNBC theranostics.

• 出版日期2018-9
• 单位海南医学院; 厦门大学