An Efficient Synthesis of N-Substituted-3-aryl-3-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)propanami des by Four-Component Reaction in Aqueous Medium

作者：Dou, Guo-Lan; Wang, De-Ming^*; Zhong, Xiao-Xing; Shi, Da-Qing

来源：Journal of Heterocyclic Chemistry, 2013, 50(1): 99-103.

DOI：10.1002/jhet.1000

• ONE-POT SYNTHESIS
• DIELS-ALDER REACTIONS
• AMIDE BOND FORMATION
• 3-COMPONENT REACTION
• MULTICOMPONENT REACTIONS
• CLAISEN REARRANGEMENT
• CATALYZED SYNTHESIS
• COUPLING REAGENTS
• CARBON-MONOXIDE
• DERIVATIVES

A mild and efficient synthesis of N-substituted-3-aryl-3-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)propanamides via four-component reaction of an aldehyde, amine, Meldrum's acid, and 4-hydroxy-6-methyl-2H-pyran-2-one in the presence of benzyltriethylammonium chloride (TEBAC) in aqueous medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions, and begin environmentally friendly.

• 出版日期2013-1
• 单位中国矿业大学（北京）; 苏州大学