Space-division multiplexing optical coherence tomography

作者：Zhou, Chao^*; Alex, Aneesh; Rasakanthan, Janarthanan; Ma, Yutao

来源：Optics Express, 2013, 21(16): 19219-19227.

DOI：10.1364/OE.21.019219

• DOMAIN MODE-LOCKING
• SWEPT-SOURCE
• ANTERIOR SEGMENT
• HIGH-SPEED
• AXIAL SCANS
• MICROSCOPY
• HEART
• OCT
• RETINA
• FDML

High speed, high resolution and high sensitivity are desirable for optical coherence tomography (OCT). Here, we demonstrate a space-division multiplexing (SDM) technology that translates long coherence length of a commercially available wavelength tunable laser into high OCT imaging speed. We achieved an effective 800,000 A-scans/s imaging speed using a 100,000 Hz tunable vertical cavity surface-emitting laser (VCSEL). A sensitivity of 94.6 dB and a roll-off of < 2 dB over similar to 30 mm imaging depth were measured from a single channel in the prototype SDM-OCT system. An axial resolution of similar to 11 mu m in air (or similar to 8.3 mu m in tissue) was achieved throughout the entire depth range. An in vivo, 3D SDM-OCT volume of an entire Drosophila larva consisting of 400 x 605 A-scans was acquired in 0.37 seconds. Synchronized cross-sectional OCT imaging of three different segments of a beating Drosophila larva heart is demonstrated. The SDM technology provides a new orthogonal dimension for further speed improvement for OCT with favorable cost scaling. SDM-OCT also preserves image resolution and allows synchronized cross-sectional and three-dimensional (3D) imaging of biological samples, enabling new biomedical applications.

• 出版日期2013-8-12
• 单位武汉大学