Secondary-Amine-Catalyzed Asymmetric Michael Addition of N-tert-Butoxycarbonyl-Protected Oxindoles to Maleimides

作者：Yang Xuena; Wang Chuan; Ni Qijian; Enders Dieter^*

来源：Synthesis, 2012, 44(16): 2601-2606.

DOI：10.1055/s-0032-1316577

• Bronsted base
• Michael addition
• heterocycles
• organocatalysis
• oxindole

A secondary-amine-catalyzed asymmetric Michael addition of 3-substituted N-(tert-butoxycarbonyl)oxindoles to maleimides with activation by a Bronsted base gives the corresponding products in high yields (86-98%), excellent diastereomeric ratios (dr > 99: 1), and high enantiomeric excesses (86-91% ee).

• 出版日期2012-8