An efficient and mild protocol for the synthesis of unsymmetrical ureas in the absence of catalyst and additives

作者：Hosseinzadeh Rahman^*; Sarrafi Yaghoub; Aghili Nora

来源：Chinese Chemical Letters, 2010, 21(10): 1171-1174.

DOI：10.1016/j.cclet.2010.06.014

• Unsymmetrical ureas
• Phenylurea
• Amines
• Uncatalyzed reaction

A new practical method for the synthesis of unsymmetrical ureas was achieved by reaction of phenylurea with primary and secondary amines under neutral and mild condition in very good yields. The reaction took place in refluxing dioxane and does not require any catalyst or additives.

• 出版日期2010-10