Advances of Succinate Dehydrogenase Mutation in Cancers

作者：Cao Zhi-Fa; Chen Wei-Cai; Yang Pei-Pei; Zhou Hai-Meng; Ou Wen-Bin^*

来源：Progress in Biochemistry and Biophysics, 2017, 44(1): 31-43.

DOI：10.16476/j.pibb.2016.0248

• SDH
• SDH mutation
• PGL
• PHEO
• RCC
• GIST

Succinate dehydrogenase (SDH), a cruciral multiprotein enzymatic complex in the Krebs cycle/transport chain, is located in the cristate of the mitochondria, and composed of A, B, C, and D subunits, which are encoded by SDHA, SDHB, SDHC, and SDHD, respectively. The SDH mutations play a crucial oncogenic role in paraganglioma (PGL, types 1-5), pheochromocytoma (PHEO), renal cell carcinoma (RCC), gastrointestinal stromal tumors (GIST), rare hypophyseal adenomas, and Leigh syndromes. Mutated SDH has been proved to be an important biomarker for diagnosis and a therapeutic target in these cancers. This review summarized and updated a variety of SDH mutations in the neoplasms and discussed the oncogenic role of SDH mutants in proliferation, apoptosis, invasion, migration, tumorgenesis and senescence.

• 出版日期2017-1
• 单位浙江理工大学; 浙江清华长三角研究院