科研之友
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摘要
A photocatalytic regeneration approach for the oxidized nicotinamide cofactors NAD(P)(+) is presented. By simple irradiation with visible light, the rate of flavin-mediated NAD(P) H oxidation is accelerated by two orders of magnitude. Catalytic use of the flavin is straightforward under aerobic conditions. Combined with alcohol dehydrogenases, photoenzymatic oxidation schemes are obtained allowing for selective, O-2-driven oxidation of primary and secondary alcohols. The simplicity and practical applicability of this oxidation approach is demonstrated in the oxidative lactonization of 1,4- and 1,5-diols. Under nonoptimized conditions, total turnover numbers of 170 and 340 are achieved for the nicotinamide cofactor and the flavin catalyst, respectively.
- 出版日期2011-2
