Association between the insulin-like growth factor axis in serum and periodontitis in the Study of Health in Pomerania: an exploratory study

作者：Harb Ali N; Holtfreter Birte; Friedrich Nele; Wallaschofski Henri; Nauck Matthias; Albers Martin; Meisel Peter; Biffar Reiner; Kocher Thomas^*

来源：Journal of Clinical Periodontology, 2012, 39(10): 931-939.

DOI：10.1111/j.1600-051X.2012.01935.x

• clinical attachment loss
• periodontitis
• serum IGFBP-3
• serum IGF-I
• tooth loss

Aim To evaluate the association of Insulin-like Growth Factor (IGF) I-related variables with periodontitis in the population-based Study of Health in Pomerania (SHIP). Material and Methods From the cross-sectional SHIP, 2293 subjects with clinical attachment loss (CAL) data and 2398 subjects with tooth count data aged 2059 similar to years were analysed. Serum IGF-I and IGF-binding protein (BP)-3 levels were determined by chemiluminescence immunoassays. Linear and logistic regressions with fractional polynomials were used to study associations between IGF-related variables and mean CAL or high tooth loss. For non-linear relations between IGFBP-3 and mean CAL, graphical presentations of fractional polynomials were used to deduce knots for linear splines. Results In fully adjusted models, for serum IGFBP-3 values =1200 similar to ng/ml, mean CAL increased significantly for decreasing serum IGFBP-3 levels [B similar to=similar to-0.027 (95% CI, -0.049; -0.005), p similar to=similar to 0.02]. The odds for high tooth loss decreased significantly for high serum IGFBP-3 values [OR similar to=similar to 0.97 (0.95; 0.99), p similar to=similar to 0.02]. Serum IGF-I levels and the IGF-I/IGFBP-3 ratio were not related to mean CAL or tooth loss after full adjustment. Conclusions Low serum IGFBP-3 levels might be associated with higher levels of periodontal disease. Neither serum IGF-I nor IGF-I/IGFBP-3 ratios were associated with periodontitis.

• 出版日期2012-10