Microwave-assisted synthesis of coumarin-3-carboxylic acids under ytterbium triflate catalysis

作者：Fiorito Serena; Genovese Salvatore^*; Taddeo Vito Alessandro; Epifano Francesco

来源：Tetrahedron Letters, 2015, 56(19): 2434-2436.

DOI：10.1016/j.tetlet.2015.03.079

• Coumarins
• Lanthanides
• Lewis acids
• Microwave synthesis
• Ytterbium triflate

Coumarin-3-carboxylic acids represent a class of natural occurring and semi-synthetic products with valuable reported pharmacological activities. In this Letter a new and improved method for the chemical synthesis of the title compounds is described. Coumarin-3-carboxylic acids have been synthesized in good to excellent yields under microwave irradiation and solvent-free conditions from differently substituted 2-hydroxybenzaldehydes or 2 hydroxyacetophenones and Meldrum's acid as starting materials in the presence of Yb(OTf)(3) hydrate 5% mol as the catalyst.

• 出版日期2015-5-6