Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model

作者：Bakri Sophie J^*; Pulido Jose S; Mukherjee Priyabata; Marler Ronald J; Mukhopadhyay Debabrata

来源：Retina-The Journal of Retinal and Vitreous Diseases, 2008, 28(1): 147-149.

DOI：10.1097/iae.0b013e3180dc9360

• antiangiogenic
• eye
• histopathology
• intravitreal
• nanogold
• rabbit
• toxicity

Purpose: To evaluate the retinal toxicity of intravitreal nanogold, a novel antiangiogenic and long-term delivery agent.
Methods: One eye of each of 16 Dutch-belted rabbits was injected with intravitreal nanogold; the other eye served as a control. Eight rabbits received a dose of 67 mu mol/0.1 mL of nanogold intravitreally into 1 eye; the other 8 rabbits received a dose of 670 mu mol/0.1 mL of nanogold intravitreally into 1 eye. Eight rabbits were killed at 1 week, and eight were killed at 1 month; both eyes of each rabbit were enucleated. The eyes were fixed with 2% paraformaldehyde and sectioned for histologic examination.
Results: In all injected and control eyes, there was mild vacuolization in the inner plexiform and ganglion cell layers. The retina and retinal pigment epithelium were otherwise histologically normal.
Conclusion: Intravitreal nanogold at concentrations of 67 mu mol/0.1 mL and 670 [mu mol/0.1 mL showed no signs of retinal or optic nerve toxicity by light microscopy during histologic examination at 1 month.

• 出版日期2008-1