Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an omega 3 rumen protected supplement containing vitamin E

作者：Trevisi Erminio^*; Grossi Paolo; Cappelli Fiorenzo Piccioli; Cogrossi Simone; Bertoni Giuseppe

来源：Italian Journal of Animal Science, 2011, 10(4): e61.

DOI：10.4081/ijas.2011.e61

• Dairy cow
• omega 3 diet supplement
• Inflammation
• Plasma omega 3 fatty acids

The aim of this research was to study the consequences of omega 3 fatty acids (FA) administration around calving on inflammatory response and on productive performances. In this period dairy cows undergo a metabolic challenge, coming with an inflammatory-like status triggering the release of pro-inflammatory mediators (e.g. eicosanoids, cytokines). Eicosanoids synthesis may be modulated by altering the ratio of their precursors (omega 3 and omega 6 FA). Ten cows received 22 g/d of rumen-protected omega 3 FA from -21 to +21 days from calving (OPT), while 10 (CTR) received no supplement. Cows were frequently monitored for health status, body condition score (BCS), blood (metabolic, inflammatory and FA profiles), milk yield. OPT (vs CTR) showed a similar milk production, a numerically smaller BCS drop, lower postpartum levels of non-esterified fatty acids (P<0.05), beta-hydroxybutyric acid (P<0.1) and creatinine (P<0.05), suggesting a milder post-calving reserves mobilization. All cows underwent an inflammatory condition around calving, but OPT showed a milder response, as suggested by lower levels of bilirubin (P<0.05), and by the higher level of Liver Functionality Index (P<0.10). Plasma concentration of omega 3 FA (eicosapentaenoic and docosahexaenoic acids) increased in OPT during treatment (P<0.01 vs CTR). Since omega 3 FA are the main replacers of arachidonic acid in membrane phospholipids, their increased levels in plasma of OPT cows may have cut the formation of arachidonic-derivatives (pro-inflammatory mediators), countering the beginning of the inflammation. Hence, the administration of rumen-protected omega 3 FA in transition period seems to attenuate the effects of subclinical inflammations and to improve the energy balance.

• 出版日期2011