An efficient homogeneous gold(I) catalyst for N-alkylation of amines with alcohols by hydrogen autotransfer

作者：Yang Hongwei; Mao Rongfang; Luo Cuicui; Lu Chu; Cheng Guangbin^*

来源：Tetrahedron, 2014, 70(46): 8829-8835.

DOI：10.1016/j.tet.2014.10.007

• Gold
• Homogeneous catalysis
• Hydrogen autotransfer
• N-alkylation

A new and highly efficient homogeneous [Ph3PAuCl]/AgOTf catalytic system was developed in N-alkylation reaction of primary amines with alcohols through a hydrogen autotransfer process. This Au(I) catalytic system shows excellent selectivity for mono-alkylation of primary amines with benzyl alcohol under moderate temperature of 100 degrees C (only secondary amines as product). The possible mechanism of this hydrogen autotransfer reaction with the catalytic system was proposed.

• 出版日期2014-11-18
• 单位南京理工大学