MRI Markers Predict Cognitive Decline Assessed by Telephone Interview: The Northern Manhattan Study

作者：Wright Clinton B^*; Dong Chuanhui; Caunca Michelle R; DeRosa Janet; Cheng Ying Kuen; Rundek Tatjana; Elkind Mitchell S V; DeCarli Charles; Sacco Ralph L

来源：Alzheimer Disease and Associated Disorders, 2017, 31(1): 34-40.

DOI：10.1097/WAD.0000000000000158

• brain volume
• white matter hyperintensities
• cognition

Background:Brain magnetic resonance imaging (MRI) allows researchers to observe structural pathology that may predict cognitive decline. Some populations are less accessible through traditional in-person visits, and may be under-represented in the literature.Methods:We examined white matter hyperintensity volume (WMHV) and cerebral parenchymal fraction (CPF) as predictors of cognitive decline measured by a modified Telephone Interview for Cognitive Status (TICS-m) in the Northern Manhattan Stroke Study, a racially and ethnically diverse cohort study. Participants were stroke-free, above 50 years old, and had no contraindications to MRI. A total of 1143 participants had MRI and TICS-m data available [mean age 70 (SD=9), 61% women, 66% Hispanic, 17% Black, 15% white].Results:Those in the third and fourth quartiles of WMHV had significantly greater decline in TICS-m over time as compared with those in the first quartile (Q3: -0.17 points/year, Q4: -0.30 points/year). Those in the bottom 2 quartiles of CPF had significantly greater decline in TICS-m than those in the top quartile (Q1: -0.3 points/year, Q2: -0.2 points/year). Apolipoprotein E (APOE) e4 allele carriers had greater cognitive decline per unit of CPF. Those with greater CPF preserve TICS-m performance better despite greater WMHV.Conclusions:Telephone cognitive assessments can detect decline due to white matter lesions and smaller brain volumes.

• 出版日期2017-3