Association of a serotonin transporter gene (SLC6A4) 5-HTTLPR polymorphism with body mass index categories but not type 2 diabetes mellitus in Mexicans

作者：Peralta Leal Valeria^*; Leal Ugarte Evelia; Meza Espinoza Juan P; Davalos Rodriguez Ingrid P; Bocanegra Alonso Anabel; Acosta Gonzalez Rosa I; Gonzales Enrique; Nair Saraswathy; Duran Gonzalez Jorge

来源：Genetics and Molecular Biology, 2012, 35(3): 589-593.

• SLC6A4 gene
• 5-HTTLPR polymorphism
• type 2 diabetes mellitus
• body mass index

The serotonergic system has been hypothesized to contribute to the biological susceptibility to type 2 diabetes mellitus (T2DM) and body-mass index (BMI) categories. We investigate a possible association of 5-HTTLPR polymorphism (L and S alleles) in the promoter region of the serotonin transporter gene (SLC6A4) with the development of T2DM and/or higher BMI by analyzing a sample of 138 individuals diagnosed with T2DM and 172 unrelated controls from the Mexican general population. In the total sample genotypes were distributed according to Hardy-Weinberg equilibrium, and S allele frequency was 0.58. There was no statistical association between 5-HTTLPR polymorphism and the development of T2DM in this Mexican population sample (p = 0.12). Nevertheless, logistic regression analysis of the L allele and increased BMI disclosed an association, after adjusting for age, sex and T2DM (p = 0.02, OR 1.74, 95% CI: 1.079-2.808).

• 出版日期2012