A new arabinoxylan from green leaves of Litsea glutinosa (Lauraeae): Structural and biological studies

作者：Das Debsankar; Maiti Swatilekha; Maiti Tapas K; Islam Syed S^*

来源：Carbohydrate Polymers, 2013, 92(2): 1243-1248.

DOI：10.1016/j.carbpol.2012.10.052

• Litsea glutinosa
• Arabinoxylan
• Structure
• Splenocyte
• Thymocyte
• Macrophage activation

A water soluble new arabinoxylan, isolated through hot water extraction from the green leaves of Litsea glutinosa (Lauraceae) was found to contain xylose and arabinose in a molar ratio of nearly 1:3. On the basis of NMR (H-1, C-13, DQF-COSY, TOCSY, NOESY, ROESY, HMBC and DEPT-135), GLC and GLC-MS analyses, the backbone was established as (1 --> 4)-alpha-D-xylopyranosyl residue, substituted at C-2 with one unit of two adjacently linked (1 --> 3)-alpha-L-arabinofuranosyl residues and the other one was terminated by beta-L-arabinofuranosyl residue. The proposed repeating unit of the molecule was established as:
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This molecule showed strong splenocyte, thymocyte, and macrophage activations. The optimum doses of the polysaccharide for splenocyte and thymocyte proliferation were observed at 25 mu g/mL and 50 mu g/mL, respectively. An enhanced production of NO was observed at 100 mu g/mL of the polysaccharide.

• 出版日期2013-2-15