Anastrozole-related acute hepatitis with autoimmune features: a case report

作者：Inno Alessandro; Basso Michele; Vecchio Fabio M; Marsico Valentina A; Cerchiaro Eleonora; D'Argento Ettore; Bagala Cinzia; Barone Carlo^*

来源：BMC Gastroenterology, 2011, 11: 32.

DOI：10.1186/1471-230X-11-32

• Anastrozole drug-induced liver injury
• autoimmune hepatitis
• hepatotoxicity
• antinuclear antibodies
• case report

Background: Two cases of acute hepatitis occurring during treatment with anastrozole have previously been reported, but the underlying mechanisms of liver injury are still uncertain. We report the case of anastrozole-related acute hepatitis with some autoimmune features.
Case presentation: A 70-year-old woman developed acute hepatitis associated with serum antinuclear antibodies during anastrozole treatment; after drug withdrawal, liver function parameters rapidly improved and serum auto-antibodies were no longer detectable.
Conclusions: Anastrozole-induced hepatotoxicity is a very rare event. Drug-drug interactions or metabolically-mediated damage might be involved, with a possible role of individual susceptibility. Our report suggests that an immune-mediated mechanism may also be considered in anastrozole-related liver injury.

• 出版日期2011-3-31