Microwave assisted synthesis of novel Hantzsch 1,4-dihydropyridines, acridine-1,8-diones and polyhydroquinolines bearing the tetrazolo[1,5-a]quinoline moiety and their antimicrobial activity assess

作者：Ladani Niraj K; Mungra Divyesh C^*; Patel Manish P; Patel Ranjan G

来源：Chinese Chemical Letters, 2011, 22(12): 1407-1410.

DOI：10.1016/j.cclet.2011.07.009

• Microwave assisted
• Tetrazolo[1,5-a]quinoline
• 1,4-Dihydropyridine
• Acridine-1,8-dione
• Polyhydroquinoline
• Antimicrobial activity

Microwave assisted efficient Hantzsch reaction via four-component coupling reactions of tetrazolo[1,5-a]quinoline-4-carbaldehyde, dimedone/cyclohexane-1,3-dione, ethyl/methyl acetoacetate and ammonium acetate was described as the preparation of tetrazolo[1,5-a]quinoline based 1,4-dihydropyridines, acridine-1,8-diones and polyhydroquinolines. The process presented here is simple, rapid, environmentally welcoming and high yielding. All the derivatives were subjected to an in vitro antimicrobial screening against a representative panel of bacteria and fungi and results worth further investigations.

• 出版日期2011-12