Use of alcohol vinegar in the inhibition of Candida spp. and its effect on the physical properties of acrylic resins

作者：de Castro Ricardo Dias^*; Loureiro Gama Mota Ana Carolina; Lima Edeltrudes de Oliveira; Dantas Batista Andre Ulisses; Oliveira Julyana de Araujo; Cavalcanti Alessandro Leite

来源：BMC Oral Health, 2015, 15(1): 52.

DOI：10.1186/s12903-015-0035-5

• Candidiasis
• Oral
• Candida albicans
• Acetic acid
• Dental prosthesis

Background: Given the high prevalence of oral candidiasis and the restricted number of antifungal agents available to control infection, this study investigated the in vitro antifungal activity of alcohol vinegar on Candida spp. and its effect on the physical properties of acrylic resins.
Methods: Tests to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of vinegar alcohol (0.04 g/ml of acetic acid) and nystatin (control) were performed. The antifungal activity of alcohol vinegar was assessed through microbial growth kinetic assays and inhibition of Candida albicans adhesion to acrylic resin at different intervals of time. Surface roughness and color of the acrylic resin were analyzed using a roughness meter and color analyzer device.
Results: Alcohol vinegar showed MIC75% and MFC62.5% of 2.5 mg/ml, with fungicidal effect from 120 min, differing from nystatin (p < 0.0001), which showed fungistatic effect. Alcohol vinegar caused greater inhibition of C. albicans adhesion to the acrylic resin (p <= 0.001) compared to nystatin and did not change the roughness and color parameters of the material.
Conclusion: Alcohol vinegar showed antifungal properties against Candida strains and caused no physical changes to the acrylic resin.

• 出版日期2015-4-28