A Comparative Evaluation of the Protective Efficacy of rMd5 Delta Meq and CVI988/Rispens Against a vv plus Strain of Marek's Disease Virus Infection in a Series of Recombinant Congenic Strains of White Leghorn Chickens

作者：Chang Shuang; Ding Zhuang; Dunn John R; Lee Lucy F; Heidari Mohammad; Song Jiuzhou; Ernst Catherine W; Zhang Huanmin^*

来源：Avian Diseases, 2011, 55(3): 384-390.

• chicken lines
• Marek's disease
• Marek's disease vaccines
• vaccine efficacy
• CVI988/Rispens
• rMd5 Delta Meq

Marek's disease (MD) is a lymphoproliferative disease of domestic chickens caused by a highly infectious, oncogenic alpha-herpesvirus known as Marek's disease virus (MDV). MD is presently controlled by vaccination. Current MD vaccines include attenuated serotype 1 strains (e. g., CVI988/Rispens), avirulent serotype 2 (SB-1), and serotype 3 (HVT) MDV strains. In addition, recombinant MDV strains have been developed as potential new and more efficient vaccines to sustain the success of MD control in poultry. One of the candidate recombinant MDV strains, named rMd5 Delta Meq, was derived from Md5, a very virulent strain of MDV lacking the MDV oncogene Meq. Our earlier reports suggest that rMd5 Delta Meq provided protection equally well or better than commonly used MD vaccines in experimental and commercial lines of chickens challenged with very virulent plus (vv+) strains of MDV. In this study, maternal antibody-positive (trial 1) and negative (trial 2) chickens from a series of relatively MD resistant lines were either vaccinated with the rMd5 Delta Meq or CVI988/Rispens followed by infection of a vv+ strain of MDV, 648A, passage 10. This report presents experimental evidence that the rMd5 Delta Meq protected significantly better than the CVI988/Rispens (P < 0.01) in the relatively resistant experimental lines of chickens challenged with the vv+ strain of MDV. Together with early reports, the rMd5 Delta Meq appeared to provide better protection, comparing with the most efficacious commercially available vaccine, CVI988/Rispens, for control of MD in lines of chickens regardless of their genetic background.

• 出版日期2011-9
• 单位吉林大学